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3.5 Ferroptosis-induced disruption of the bloodbrain barrier in Alzheimers disease The bloodbrain barrier (BBB) is a critical structural interface that maintains central nervous system (CNS) homeostasis by restricting the translocation of blood-derived substances, inflammatory mediators, iron ions, and immune cells into the brain parenchyma through its tight junction architecture
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Studies have demonstrated a consistent year-on-year escalation in patient suicides associated with medication use, intensifying concerns among the general public and clinical professionals regarding this phenomenon [16,17,18]
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