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One prior report described PSD95-positive elements contacting intestinal enterochromaffin cells of the mouse 39 , but neither provided quantitative data nor proof of staining specificity
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The STEP trial programme (which primarily enrolled adults without type 2 diabetes) showed that participants with obesity achieved an average weight loss of approximately 15% of their initial body weight over 68 weeks, compared to 2.4% with placeboall participants also received lifestyle intervention
According to a study on metabolic effects of gastric bypass surgery, increases in GLP-1 secretion play an important role in weight loss and improved metabolism after surgery
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