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[10] In the 12-week study on middle-aged women cited above, the researchers found that HMB has an incredible ability to reduce intramuscular adipose tissue (IMAT), a type of fat infiltration within muscle tissue that can compromise metabolic health

Thus, by promoting intimal hyperplasia, these vascular disorders (which are related to smooth muscle cell proliferation, collagen accumulation, and the extracellular matrix modification that may result from homocysteinylation of the vascular wall structure leading to connective tissue deterioration) might contribute to the atherogenic tendency of hyperhomocysteinemia

The medication is administered via subcutaneous injection, typically on a weekly basis, though dosing frequency and amounts may be individualized based on patient response and tolerability