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doi: 10.1016/j.redox.2017.11.001 56 ZhaoW.ZhangL.ChenR.LuH.SuiM.ZhuY.et al
Enhanced activity of IDO enzymes (IDO-1 and IDO-2) shifts tryptophan metabolism towards the kynurenine pathway, leading to increased concentrations of kynurenic acid (KYNA) within the CNS (216220)
TOPLINE: The use of GLP-1 receptor agonists was linked to lower pain and fatigue in patients with fibromyalgia, according to a large-scale health records analysis
In the Phase 2 trial, participants who skipped lower doses and jumped directly to higher ones experienced nearly double the rate of GI side effects compared to those who followed the full titration schedule
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