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Also, the male KO mice had an increased CYP1A2 (Part of the P450 enzyme family that are responsible for a large part of detoxification), however this wouldnt really explain the differences seen in Figure 2 (side-note: Ok, this last part was extremely geeky and I try to make this as mainstream as possible
Testosterone, estrogen, progesterone, cortisol, thyroid hormones, gonadotropins, and binding proteins all influence one another, so hormone assessment should be treated as a network problem rather than a one-number problem
A change in FDA leadership, new safety requirements, or shifts in regulatory philosophy could add review time
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