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Although there are some cardioprotective benefits to LC supplementation in certain situations (such as lowering all-cause mortality after MI), the formation of TMAO that goes along with it raises questions regarding long-term cardiovascular safety, particularly for people who already have heart issues [83]

Nonetheless, future studies should prioritize the development or adoption of specialized tools designed specifically for this clinical profile, ensuring these are subjected to comprehensive psychometric validation

Due to its poor absorption and rapid metabolism in the body, curcumin is often ingested in combination with black pepper, as it contains piperine, which increases the effectiveness of curcumin in the body by about 20 fold 7