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Participants were excluded if they had significant medical histories, abnormal lab results, or conditions affecting alcohol metabolism or absorption of the investigational product

Regular monitoring of renal function is advisable in patients with pre-existing kidney disease, as gastrointestinal adverse effects may lead to dehydration and acute kidney injury

This study also showed that GLP-1 and the GLP-1MK-801 conjugate promote enhanced whole-body lipid oxidation, evident by a decrease in respiratory exchange ratio (RER) compared with vehicle or MK-801 treatment (Extended Data Fig

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