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Together, our data suggest that secondary sulfonylurea failure may reflect islet cell reprogramming and loss of -cell identity, rather than simple -cell exhaustion To view or add a comment, sign in Clinical Efficacy of Second-Generation Tetracyclines as First-Line Systemic Agents for Gingival Lichen Planus In a recent JDD report of 254 biopsyconfirmed patients whose erythematous or erosive gingival oral lichen planus failed topical therapy, a 2month course of doxycycline or minocycline (100 mg twice daily), given alongside topical agents, produced clinical improvement in about 61% of patients
Immunohistochemistry (IHC) demonstrated positivity for S100 , negativity for Melan-A and HMB45 , and a Ki-67 index of 0%
And with the weight loss benefits comes an improvement in obesity-related medical conditions such as hypertension, type 2 diabetes, sleep apnea, and cancers
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