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Like Stelara, it is administered through an IV infusion

Tighten may also provide antioxidant and anti-inflammatory benefits, helping to soothe irritation and promote overall skin health

Mild stomach upsets Nausea or feeling uneasy Loose motions in some cases Headache Allergic reactions such as rash or itching on the skin (rare) Bloating or gas

NICE and British Society for Haematology guidelines recommend: Initial treatment with hydroxocobalamin (the preferred form in the UK) via intramuscular injection For patients without neurological involvement: 1 mg IM three times a week for 2 weeks For patients with neurological involvement: 1 mg IM on alternate days until no further improvement Maintenance: 1 mg every 3 months for patients without neurological involvement