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En particular, la glutatin reductasa pareciera ser una buena diana teraputica para la accin de antimalricos, ya que la glutatin reductasa del parsito Plasmodium falciparum es significativamente diferente en cuanto a estructura y plegamiento a la glutatin reductasa de los mamferos

Vitamin B12 and folic acid deficiencies cause high homocysteine levels, which have been associated with increased atherosclerosis, stroke, arterial clots, and venous thrombosis risk

However, the necessity of GPxs for eukaryotic cells is justified considering that GPx can neutralize not only inorganic (hydrogen peroxide) but also organic peroxides (including lipid hydroperoxide)

The refinement stage utilised AMBER (Assisted Model Building with Energy Refinement), a force field commonly used in molecular dynamics simulations