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Further evidence for the hypothesis that glutathionylation is not supported by a suitable scaffold site in ROXY9 comes from the observation that Cys22 of the ROXY9-C 21 C 22 LS variant started to become glutathionylated at roughly the same redox potential as Cys21, albeit Cys22 is not oriented towards the GSH binding groove (Fig
134 NotkolaI
Folate also directs cysteine to glutathione production and away from homocysteine production
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