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Compelling data endorsing value of bariatric surgery when compared to GLP1
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These residues are located at the base of the GLP-1R binding pocket in the cryo-EM structures and interact with residues in TMs 1, 2 and 7 (Figs
Along with the possible paracrine effect of intestinal GLP-1, it is assumed that the effect of GLP-1 on food intake is controlled by two separate groups of vagal afferents, although the central mechanisms processing anorexic vagal nerve signals have not been fully studied [9]
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