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In addition to its incretin action, GLP-1 acts on the GLP-1 receptor (GLP-1R) in the brain to suppress feeding
Glucose-dependent insulinotropic polypeptide (GIP) inhibits bone resorption independently of insulin and glycemia
Consistent with this, using cyanine 5 (Cy5) peptide labelling, we observed equal efficacy of the GLP-1RA and the GLP-1RA/tesaglitazar conjugate to reach the ARC (Extended Data Fig
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The post says GLP-1 therapy may not produce significant weight loss in non-overweight patients, but that improved glucose control, cardiovascular protection, and reduced inflammation remain clinically meaningful
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