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Excessive and prolonged stimulation of the somatotropic axis could theoretically induce effects similar to acromegaly: fluid retention, arthralgia, carpal tunnel syndrome, insulin resistance, and potentially an increased risk of proliferation of certain IGF-1-sensitive tumor cells

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Piltonen T, Koivunen R, Ruokonen A, Tapanainen JS

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SN neuromelanin can be clearly seen when primary antibody is omitted (Figure 1B)

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