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Some preliminary research suggests berberine may indirectly increase endogenous GLP-1 secretion from intestinal cells, but this effect is fundamentally different from directly activating GLP-1 receptors
The unique triple-agonist mechanism (GLP-1 + GIP + glucagon) has not produced unexpected safety signals beyond those anticipated from the individual receptor mechanisms
"They're concerned and they're frustrated, so that's why some of them have bought three months supply, " Head said
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