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This study was performed at Masaryk University as part of the project Preclinical and clinical research at the Institute of Pharmacology: Pharmacokinetics, behavioral neuropsychopharmacology, and personalized pharmacotherapy number MUNI/A/1819/2025 with the support of the Specific University Research Grant, as provided by the Ministry of Education, Youth and Sports of the Czech Republic in the year 2026

however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development

Later work has built on that finding, including a 2023 peer-reviewed review on MOTS-Cs role in metabolic disorders