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Specific proteins in this supplement such as lactoferrin, serum albumin, alpha-lactalbumin, and immunoglobulins, are rich in cysteine and cystine residues, which are bioavailable for cellular absorption and subsequent glutathione synthesis

A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

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In vivo L2-Cmu validation studies were performed in 45-mo-old C57BL/6J male mice (Jackson Labs, Bar Harbor, ME)