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This glutathione depletion is not merely a consequence of the disease - it is thought to be a contributing driver of disease progression, creating a vicious cycle: oxidative stress depletes glutathione reduced glutathione allows more oxidative damage more protein oxidation stronger autoimmune response more thyroid destruction more oxidative stress

Interestingly, some patientsespecially those with PCOSexperience *improved* cycle regularity because GLP-1 therapy reduces insulin levels and supports metabolic health

Persistent nausea, repeated vomiting, or inability to tolerate food and fluids can lead to dehydration and nutritional deficiencies

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