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Legal & Market Shifts During shortages, FDA authorized temporary compoundingthough name brands have now resumed supply
However, starting with an SGLT2 inhibitor or a GLP-1 RA in an individual who is intolerant to metformin (primarily diarrhea) is a good choice, and even in the future we may see large diabetes organizations recommending these two classes as first line therapy once they get less expensive.
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Patients should monitor blood glucose closely and work with healthcare providers to titrate diabetes medications appropriately, often requiring proactive insulin or sulfonylurea dose reductions
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