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& Kerkvliet, N

Findings published in a preprint from a phase I clinical trial on the GLP1glucagon receptor co-agonist NN1177 in adults with overweight or obesity have raised problems with deterioration of glucose tolerance and other safety concerns, despite inducing weight loss, which illustrates the difficulties in getting the agonist balance right during the preclinical development of co-agonist therapies 6,7

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Interestingly, FXR agonists and inhibitors displayed beneficial effects on metabolic disorders, requiring more in-depth research