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The GLP-1 receptor pathway Glucagon-like peptide-1 is secreted by L-cells in the distal small intestine and colon in response to food intake

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During metabolic stress, the Sigma-1 receptor (S1R) plays a pivotal role in stabilizing IP3Rs at the contact site, preventing their degradation and maintaining the bioenergetic flow required for cellular survival (Hayashi and Su, 2007

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