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Resist 22 , 133134 (2020)

Tapering Considerations: Gradually reduce GLP-1 dosing while increasing fiber and protein intake Begin nutraceutical support (e.g., berberine, chromium) 24 weeks prior to taper Monitor lean mass and glycemic variability Support appetite signaling with mindful eating and circadian regulation Address gut motility and emotional eating patterns with botanical support Clinical Example: A Case in Practice A 52-year-old female on semaglutide for 6 months presented with nausea, fatigue, and concern about lean mass loss

Daily oral orforglipron, a nonpeptide GLP-1 receptor agonist, was associated with weight reduction [30] [31], offering potential advantages regarding administration route and patient convenience

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