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Extracellular calcium and cAMP: second messengers as third messengers
This effect is achieved through the activation of signaling pathways such as the ERK1/2, PI3K/AKT, and cAMP/PKA/-cat-Ser675 pathways, which are mediated by GLP-1RAs
Although an association with urinary congenital malformations was identified, it was based on limited unadjusted data and may reflect confounding by maternal diabetes or obesity rather than a true treatment effect
Biologics License Application (BLA), not NDA: Retatrutide is regulated as a biologic, so Lilly will file a BLA rather than a small-molecule NDA
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