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Pathophysiology of Acetaminophen Toxicity Now that weve gone over the basic pharmacokinetics of acetaminophen, lets talk about the pathophysiology of acetaminophen toxicity

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OTA reduces the expression of several genes regulated by nuclear factor-erythroid 2 p45-related factor (Nrf2) and reduces the expression of antioxidant enzymes through inhibition of Nrf2 [62, 63]

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