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Central appetite suppression: Amylin crosses blood-brain barrier Activates area postrema (brainstem) Also acts on nucleus accumbens Direct satiety signaling Reduces desire to eat Different brain pathways than GLP-1 3
This fundamental difference drives the efficacy gap
Some clinical observations suggest that while the dual action can lead to more significant weight loss, it may also lead to a more pronounced feeling of tiredness in the initial stages compared to GLP-1 alone
The energy and clear mind have helped incredibly
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