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The primary concern relates to the gastrointestinal effects of GLP-1/GIP medicines
It is categorized into three distinct subtypes based on left ventricular ejection fraction (LVEF): heart failure with preserved ejection fraction (HFpEF), heart failure with mid-range ejection fraction (HFmrEF), and heart failure with reduced ejection fraction (HFrEF)[2]
Blood Sugar and Metabolic Benefits For tirzepatide at low doses, glucose control improved significantly across fasting and post-meal measurements. Markers of pancreatic function showed substantial improvement, suggesting GLP-1s protect the cells that produce insulin. This could explain why metabolic benefits last beyond treatment
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