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The lid peptides in these two PTL crystal structures and our LPL dimer have shifted into an open state, exposing the active site (Fig
These medications have long half-lives (the time it takes for the amount of a drug's active substance in your body to reduce by half), so starting a new treatment too soon can: Increase the risk of side effects, Reduced effectiveness Overlap drug activity, making unclear which drug is causing which reaction, and the new therapys true effects may be masked
The homogenates were centrifuged at 20,400 g for 20 min at 4 C, and the resulting supernatants were appropriately diluted and used in the assays, which were conducted according to the manufacturers instructions
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