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Duracin de accin: Mientras que el GLP-1 natural tiene una vida media de aproximadamente 2 minutos, los agonistas sintticos varan significativamente: [1] [3] Exenatida de accin corta: 2.4 horas (requiere dos dosis diarias) Liraglutida: 13 horas (una dosis diaria) Dulaglutida: aproximadamente 5 das (una dosis semanal) Semaglutida: aproximadamente 7 das (una dosis semanal) Estas diferencias en la duracin permiten un control glucmico sostenido y mejoran la adherencia al tratamiento