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Key Takeaways Tirzepatide activates two incretin hormone pathways (GLP-1 and GIP)
Significance for heterogeneity was set at p 50% considered to be evidence of substantial heterogeneity
The slight difference in semaglutide dose between administration in IcoSema (0.114 mg) and administration alone (0.1072 mg) was due to the difference in semaglutide concentration between IcoSema (2 mg/mL) and semaglutide alone (1.34 mg/mL) combined with the injection volume equivalent to each increment on the PDS290 pen injector
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