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Nevertheless, it is crucial to consider the potential adverse effects of weight fluctuation after discontinuing these medications, particularly the increased risk of cardiovascular and all-cause mortality in patients with obesity or overweight
However, humans and monkeys express lower levels of the GLP-1 receptor in thyroid C-cells than rodents, and GLP-1 receptor agonists are unlikely to stimulate adenylate cyclase or increase calcitonin release in primates [65]
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