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[1] The most frequently reported adverse effects in clinical trials were gastrointestinal in nature, including nausea (12-22%), diarrhea (12-16%), vomiting (6-10%), and constipation (6-7%), with rates varying by dose

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This multifaceted approach includes: 1

Further analysis confirmed that FOXO4-positive cells co-expressed Leydig cell markers, specifically StAR and CYP11A1, indicating that FOXO4 is indeed expressed in human Leydig cells [1]