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Moreover, preliminary data from real-world studies show a better metabolic control of T2DM patients with oral semaglutide, which is related to good treatment adherence [98, 99]
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Therefore, it is plausible that the effect of PGC-1 overexpression we observed did not rely only on these two transcription factors, but that it was mediated also by other factors, that finally contributed to the deleterious outcome