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For general context, see peer-reviewed articles in major journals (reading list below)

Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

The location depends on what is most accessible, most comfortable for you, and where there is some adipose (fat) tissue

In clinical research settings, this difference matters most in how each compound is measured: Tesamorelin has been studied in trials involving GH and IGF-1 level changes, while AOD-9604 research has focused specifically on lipolysis and fat oxidation markers without the same IGF-1 elevation a distinction documented in peer-reviewed pharmacology literature comparing hGH fragments to full GHRH analogs