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However, discontinuation rates in Phase 2 were low (~6% at 12 mg), which suggests side effects were manageable for most participants
This makes overdose extremely rare , but that doesnt mean more is always better
What we have is a plausible biological hypothesis (collagen peptide supplementation provides the amino acid substrates that bone matrix formation depends on, which may be relevant when those substrates are being depleted by rapid weight loss) supported by a strong positive RCT in a related population - and no direct evidence yet in the GLP-1 therapy population specifically
Depression is linked to hyperglycaemia via suboptimal diabetes self-ma nagement: a cross-sectional mediation analysis
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