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However, the therapeutic index of doxorubicin is undermined by dose-dependent cardiotoxicity, which may be a function of futile redox cycling
One aliquot was treated with 10 M compound 6a (achieved by adding 1.7 l of a 10 mM DMSO stock to 1.7 ml sample, yielding 0.1% DMSO final concentration), while the control aliquot received an equivalent volume of DMSO alone
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