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These neurofunctional changes can start an autovicious cycle in which various systems and mechanisms are exacerbated and accelerate cell damage, resulting in progressive structural brain changes and impairment of frontal cognitive functions

Albaker, W., Al Sheikh, M., Albakr, A., Alkhafaji, D., Al Besher, E., & Al-Hariri, M

Classic symptoms The most recognizable symptom is a burning sensation in the chest that rises from the upper abdomen toward the throat

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