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Attenuation of epidermal growth factor (EGF) signaling by growth hormone (GH)
pH extremes: GHK-Cu shows reduced stability at very acidic or very alkaline pH
These include: Medullary thyroid carcinoma (MTC): Retatrutide is contraindicated in individuals with personal or family history of thyroid cancer, such as medullary thyroid cancer or Multiple endocrine neoplasia syndrome type 2 (MEN 2), because this medication can increase the risk of thyroid C-cell tumors
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