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The down-regulation response to adenosine is not mediated through G-protein-coupled adenosine receptors, but occurs through an increase in tyrosine protein phosphatase activity resulting in a decrease in the tyrosine phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen activated protein kinase (MAPK) that leads to an alteration in DPP4 mRNA
Sci Adv 9(44):2884 Anand BK, Brobeck JR (1951) Localization of a feeding center in the hypothalamus of the rat
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