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In the brain of patients with mild cognitive impairment (MCI) and those with AD, the level of markers of oxidative damage to DNA, proteins, and lipids is increased, while the expression and activities of glutathione and antioxidant enzymes are reduced (reviewed in 102)
Each monomer of a cytosolic GST is composed of an N-terminal domain (domain I) and C-terminal domain (domain II)
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Create a restful environment by minimizing noise, limiting screen time before bed, and using blackout curtains if needed to avoid disrupted sleep
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