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The trans-3-hexenoyl group on the N-terminal tyrosine acts as a protective cap against dipeptidyl peptidase-IV (DPP-IV), the enzyme that cleaves native GHRH between residues 2 and 3 and generates the short plasma half-life that limits unmodified GHRH activity
When used together, these peptides start two paired pathways for growth hormone release, producing greater GH rise than either peptide alone
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Mohammad Zamani 1, Naseh Pahlavani 2 3, Mahlagha Nikbaf-Shandiz 4, Niloufar Rasaei 5, Rasool Ghaffarian-Ensaf 6, Omid Asbaghi 7 8, Farideh Shiraseb 5, Samira Rastgoo The effects of L-carnitine supplementation on glycemic markers in adults: A systematic review and dose-response meta-analysis National Library of Medicine, 2023 Jan 10:9:1082097
