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In the TRIUMPH-1 Phase 3 trial, participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks, and up to 30.3% at 104 weeks in the study extension

Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies

The FDA and European Medicines Agency have reviewed available data and concluded that while pancreatitis should be considered a potential risk, the evidence does not support withdrawing these medications from the market