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Current guidelines from the American Society for Metabolic and Bariatric Surgery (ASMBS) and International Federation for the Surgery of Obesity (IFSO) support consideration in patients with BMI 35 kg/m regardless of comorbidities, or BMI 30-34.9 kg/m with metabolic disease
Subsequently, IRF3 is phosphorylated by TBK1 in the complex, which promotes IRF3 homodimerization and translocation to the nucleus to further regulate the expression of a series of genes
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