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Peer review Peer review information Nature Communications thanks Kathrin Ulrich and John Mieyal for their contribution to the peer review of this work

95% CI, 0.860.94

Common research-planning ranges (subcutaneous) Planning band Low Per-dose range ~250 mcg Frequency Once daily Typical context Maintenance / general research planning Planning band Standard Per-dose range ~250 mcg Frequency Twice daily Typical context Most published preclinical protocols and community references Planning band High Per-dose range ~500 mcg Frequency Twice daily Typical context Short-term acute-injury research planning These ranges reflect community-derived research planning

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