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The GHK-Cu complex adopts a square-planar geometry, coordinated through the nitrogen atoms of the imidazole ring of histidine, the -amino group of glycine, and the deprotonated amide nitrogen of the glycine-histidine peptide bond
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Studies have examined the relationship between NNMT inhibition and cellular NAD+ levels, which are critical for numerous enzymatic reactions including those involving sirtuins and PARPs
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