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An exploratory analysis of those formerly using insulin in conjunction with GLP-1 receptor agonist (who were originally excluded from the main analysis) showed an increase in HbA1c (1.2%1.3%, P =0.006) (Supplemental Table S1), suggesting that the insulin dose adjustments made after discontinuing GLP-1 receptor agonists were insufficient to maintain glycemic control
However, long-term studies specific to addiction treatment are required to confirm their safety in this new application
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Retatrutide (research phase) Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors
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