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Rather than outright banning compounded GLP-1 medications, expert associations can contribute to the solution by creating a seal of approval, recognizing high-quality compounded medications

For patients who are not well-controlled on a treatment with metformin and basal insulin, a treatment intensification with a DPP-4 inhibitor may be feasible

The tirzepatide to semaglutide transition typically involves starting semaglutide at a moderate dose (0.5mg or 1.0mg weekly) rather than the standard 0.25mg starting dose, since the body is already adapted to GLP-1 receptor activation

By striving to reconcile the disparity between its considerable neuroprotective potential and recent clinical challenges, we can enhance our understanding of the potential role of semaglutide and other GLP-1 receptor agonists in combating cognitive decline