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[60] The zona incerta, grouped between the arcuate and periventricular nuclei, projects to several areas of the hypothalamus, and participates in the control of gonadotropin-releasing hormone, which is necessary to activate the development of the male and female reproductive systems, following puberty

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Physical inactivity, by contrast, promotes mitochondrial stagnation, impaired fatty acid oxidation, and chronic oxidative stress, further depleting glutathione reserves

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