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JACC: Basic to Translational Science

The answer appears to be nuanced, with some conflicting data, but a few themes have emerged: Insulin and hormonal cross-talk: GLP-1 RAs improve insulin sensitivity and lower insulin levels (especially in obese insulin-resistant men)

70 In C57BL/6J mice, CR promoted stress resistance in a FOXO1-dependent manner, 71 which would not occur in tumor cells with FOXO inactivation due to constitutively active AKT