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Without adequate glutathione reserves, acetaldehyde accumulates in hepatocytes and crosses the blood-brain barrier, where it disrupts neurotransmitter synthesis and causes the cognitive symptoms of hangover

Although antioxidants such as glutathione can lead to a variety of health benefits, their key role is to inhibit oxidation and damage to cells from free radicals (hence anti-oxidant)

Yet most people still dont fully understand how they work, their benefits, or where the real risks lie

Additionally, NAD + is required for fatty acid metabolism during -oxidation, glutaminolysis generating -ketoglutarate, mitochondrial shuttling of metabolites, and lactic acid fermentation 3,4,5