tirzepatide and sleep issues Side Effects Insomnia: What the Evidence Shows The FDA approved Zepbound in

The drug works by mimicking these hormones and targeting their receptors in the brain, which play a role in regulating your appetite and blood sugar levels

Both medicines affect GLP-1 pathways and share a dominant side-effect profile: nausea, vomiting, diarrhoea, constipation and abdominal discomfort, especially during dose escalation

(Figure 1) Figure 1: Mean insulin concentration at 0-120 minutes during hyperglycemic clamp at baseline and Week 28 SPL UNCLASSIFIED SECTION Insulin Sensitivity Tirzepatide increases insulin sensitivity, as demonstrated in a hyperinsulinemic euglycemic clamp study after 28 weeks of treatment

The clinical trial protocol allowed for dose delays when side effects were intolerable